Hollywood is mourning the loss of one of its most recognisable leading men. Eric Dane, best known for his role as Dr Mark Sloan, nicknamed “McSteamy”, on Grey’s Anatomy, has died at the age of 53 following a battle with amyotrophic lateral sclerosis (ALS).
His family confirmed that he passed away on Thursday afternoon.
“With heavy hearts, we share that Eric Dane passed on Thursday afternoon following a courageous battle with ALS,” a family statement read.
He is reported to have spent his final days surrounded by loved ones, including his wife Rebecca Gayheart and their two daughters, Billie and Georgia.
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A courageous battle with ALS
Dane publicly revealed his ALS diagnosis in 2025, sharing that he had been experiencing symptoms for over a year and a half before going public.
ALS, also known as Lou Gehrig’s disease, is a rare and progressive neurological disorder that affects nerve cells in the brain and spinal cord. The condition gradually robs individuals of the ability to move, speak and eventually breathe.
Throughout his illness, Dane became an advocate for ALS awareness and research, using his platform to highlight the realities of the disease.
“Throughout his journey with ALS, Eric became a passionate advocate for awareness and research, determined to make a difference for others facing the same fight,” his family said.
From breakout heartthrob to television icon
Born in San Francisco in 1972, Dane’s early life was marked by tragedy after losing his father at the age of seven.
He made his television debut in a 1991 episode of Saved by the Bell and went on to land guest roles in shows including The Wonder Years and Charmed. But it was his arrival on Grey’s Anatomy in 2006 that transformed his career.
Introduced as the charismatic plastic surgeon Dr Mark Sloan, Dane’s chemistry, charm and vulnerability quickly turned what was meant to be a guest appearance into a starring role.
He appeared in 139 episodes of the hit medical drama and remained one of its most beloved characters until his departure in 2012. His character’s tragic storyline marked the end of an era for many longtime fans.
Dane later reflected that there was a strong personal connection to the role, saying in past interviews that he felt an artistic responsibility to embrace every facet of Mark Sloan’s complexity.
A career beyond ‘McSteamy’
While Grey’s Anatomy made him a household name, Dane continued to expand his range long after leaving Seattle Grace.
He starred as Captain Tom Chandler in TNT’s post-apocalyptic drama The Last Ship from 2014 to 2018, showcasing a commanding on-screen presence.
More recently, he earned critical acclaim for his role as Cal Jacobs in HBO’s Euphoria, portraying a deeply conflicted father leading a double life. The performance introduced him to a new generation of viewers and reaffirmed his versatility as an actor.
Remembering a beloved star
Tributes from fans and colleagues have poured in following news of his passing, with many remembering him not only for his iconic roles but for the warmth and charisma he brought to the screen.
His family described him as a devoted husband and father, saying he adored his fans and was deeply grateful for their support throughout his career and illness.
Eric Dane leaves behind a legacy defined by unforgettable characters, resilience in the face of adversity and a smile that once lit up television screens around the world.
He was 53.
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